Small-fiber Neuropathy in a patient with PMP22 gene single-nucleotide sequence variation, Coxsackie virus, HSV-1, HSV-2, HHV-3 and HHV-4 Infection: A Case Report.
Neurology at Vital-Klinik, Bahnhofstr. 3, 33014 Bad Driburg, Germany, Email: s_bucurescu@yahoo.com
Citation: Dr. Septimiu Tudor Bucurescu., “Small-fiber neuropathy in a patient with PMP22 gene single-nucleotide
sequence variation, Coxsackie virus, HSV-1, HSV-2, HHV-3 and HHV-4 infection: a case report”. American Research
Journal of Neurology, Volume 4, Issue No. 1, 2021, pp. 1-5.
Abstract
In this paper we discuss the case of a small-fiber neuropathy patient with heterozygous gene mutation, a single-nucleotide sequence variation c.353C>T in
peripheral myelin protein 22 (PMP22) gene. The patient was diagnosed with a current infection with Coxsackie virus, herpes simplex virus type 1 (HSV-1) and
2 (HSV-2), as well as a previous infection with human herpesvirus 3 (HHV-3 or varicella-zoster) and 4 (HHV-4 or Epstein-Barr). We also discuss the diagnosis
and therapy of patients with small-fiber neuropathy. With regard to etiology, future studies must clarify if viruses are causing small-fiber neuropathy directly
through lytic replication or indirectly through release of viral proteins and neurotoxic substances from macrophages. The efficacy of antiviral drug treatment
in infectious small-fiber neuropathy needs clarification.
