American Research Journal of Gynaecology

Objective: to assess the reproductive outcome (ovulation rate and pregnancy rate) in relation to a proposed Edessy ovarian reserve score after different methods of ovulation inductions.

Patients and Methods: 200 primary infertilitywomen due to PCOS were recruited for the study that conducted in Obstetrics and Gynecology Department Of Al-Azhar university hospital at Assiut from October 2015 to June 2016..Patients were classified into four groups according to methods of ovulation induction (50 patients for each): Group I: clomide, Group II: metformin +clomid, Group III:letrozole and Group IV: laparoscopic ovarian drilling. Patients included in this study wereevaluated according to Edessy Ovarian Reserve Score(EORS).

Results: ovulation rate was 76.9%, 75%,61.5% and 71.2% for group I, II, III and IV respectively. Pregnancy rate was 42.3%, 59.6%, 28.8% and 38.5% for group I, II, III and IV respectively.There were significant negative correlations between ORS and FSH, E2. There were significant positive correlation between ORS and AMH, AFC and MOV. Also, there were significant positive correlation between ORS and ovulation and pregnancy rate. In our study There is significant positive relationship between pregnancy rate and ORS (37% 0f pregnancy in all subgroups were EORS ≥ 5 while 6.5%of pregnancy in all subgroups were EORS <5)

Conclusions and Recommendations: This study suggests that ORS that used in this study is useful for prediction of poor response to controlled ovarian hyperstimulation (COH), prediction of pregnancy rate and counseling the couples regarding their performance during ovarian stimulation.Our results suggest that AFC and AMH are better than age, FSH, E2 and MOV as regard prediction of response to COH and also in prediction of pregnancy rate. We recommend using AFC and AMH as routine markers of ovarian reserve and for prediction of poor responders for COH.