Hepatotoxicity Implies Chemical-Driven Liver Damage Induced By Certain Medicinal and Other Chemical Agents
1Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Assuit, Egypt,
2Department of pharmacology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt,
3Department of physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
Abstract
There are increasing evidences that free radicals and reactive oxygen species play a crucial role in the various steps
that initiate and regulate the progression of liver diseases. Oxidative stress in hepato-toxicity resulting from
increased generation of reactive oxygen species (ROS) and other reactive intermediates as well as by decreased
efficiency of antioxidant defenses actively contributes to excessive tissue remodeling. Drug-induced nephropathy is
reported to be the third most common cause of acute renal failure in hospitalized patients. Excess ROS production
and depressed antioxidant defence mechanism are responsible for nephrotoxicity.So, pharmacological studies in this
work were done to evaluate: presence of protective effects of an antioxidant Hesperedine on carbon tetrachloride
induced hepatic toxicity and nephro-toxicity, to evaluate its effects on oxidants and antioxidants parameters and to
evaluate its effect on kidney and liver functions and histo-pathological changes.Liver enzymes level AST and ALT
: was increased significantly in rats treated with CCl4 but decreased significantly in rats treated with antioxidant
HDN (100 mg/ kg/ day) and in rats treated with antioxidant HDN (200 mg/ kg/ day) . in comparison between
antioxidant treated rats groups liver enzymes level was decreased significantly in rats treated with antioxidant HDN
(200 mg/ kg/ day) than in rats treated with antioxidant HDN (100 mg/ kg/ day) .Serum creatinine level: was
increased insignificantly in rats treated with CCl4 but decreased insignificantly in rats treated with antioxidant HDN
(100 mg/ kg/ day) and in rats treated with antioxidant HDN (200 mg/ kg/ day). in comparison between antioxidant
treated rats groups liver enzymes level was decreased insignificantly in rats treated with antioxidant HDN (200 mg/
kg/ day) than in rats treated with antioxidant HDN (100 mg/ kg/ day) . So, we recommend uses of antioxidant
Hesperedine as it has a valuable role in improvement of liver functions and as a prophylactic of hepatic and renal
tissues against toxicity achieved by free radicals.
