American Research Journal of Dermatology

Aicha Nassiri kaoutar MoustaideNiema Aqil Hanane Baybay Fatima Zahra Mernissi

 Radiodermatitis can cause a real discomfort for patients and can lead to the cessation of the treatment. The aim of our study was to identify different factors regulating acute radiodermatitis. Material and Methods: From January 2016 to December 2017, We conducted a prospective trial with collaboration of dermatologist and radiotherapist of hassan II hospital in Fez. Results: Radiodermatitis stage 1 were found in 20%. The predominent irradiated area in this stage was face and neck in 42% and breast in 27%. Radiodermatitis stage 2 were seen in 40%. 41% in head and neck and 24% in the breast. Radiodermatitis stage 3 were found in 23%. Radidermatitis STAGE 3 were seen only in 3 areas : perineal area (59%), face and neck (22%), breast (19%). Radiodermatitis stage 4 in 17% seen only in 2 areas : perineal 72%, face and neck in 27%. Conclusion: Radiodermatitis is one of the most common side effects experienced by patients undergoing radiotherapy. In our study the factors influencing radiodermatitis were age of the patient, sexe, obesity, smoking, perineal location, photoexposed areas, higher radiation doses. : Acute radiodermatitis, regulating factors, Radiotherapy side effects

Fatma Frikha MD, Emna BahloulMD, Abderrahmen Masmoudi, Ph.D, Madiha Mseddi, ph.D Meriem Amouri, Ph.DHamida Turki, Ph.D

 Penile erysipelas is rarely described and not well characterized. Therefore we aim to describe the clinical characteristics, and risk factors of this erysipelas type. Methods: a retrospective study of all clinically diagnosed cases of penile erysipelas during 18 years. For each patient, epidemiologic, clinical and therapeutic profiles were reported. Results: fourteen cases of penile erysipelas were diagnosed (0.67% of all erysipelas patients). Mean age was 49 years. All patients had erythema, edema and pain in the penile region. Scrotal involvement was seen in 3 cases. Only one patient had phlyctenular lesions. The inguinal lymph nodes were enlarged bilaterally and painful on palpation in 13 cases (93%). This cellulitis was a consequence of balanitis due to incomplete circumcision (2 cases), to sexual trauma (2 cases), direct trauma (2 cases), folliculitis (1 case) and inguinal intertrigo (1 case). Antibiotics were sufficient to obtain recovery in 13 cases. One of the patients, developed gangrene and underwent surgical operation. Conclusion: Penile erysipelas looks to be favored by poorly done circumcision and micro trauma of the penis. Appropriate antibiotics must be administrated as soon as possible to prevent evolution into gangrene. Keywords: Erysipelas, Cellulitis, erysipelas penis, incomplete circumcision, antibiotics

Faranak MavandadnejadFatemeh RafiiElnaz Faghfuri Narges Mokhtari-NoriSasan Rezaie Ahmad Reza Shahverdi

 Fungi in the genus Malassezia are involved in skin disorders, including dandruff and seborrheic dermatitis, two commonly recurring scalp conditions that are often treated with selenium-containing materials. The antifungal effects of SeS2 and SeNPs against M. sympodialis and M. furfur were compared. The results showed that SeNPs had higher antifungal activity than SeS2 against both species. Both preparations were more effective against M. sympodialis than against M. furfur. Post-antifungal effects were not observed for M. furfur after short exposure to either SeNPs or SeS2 . However, cultures treated for a short time with the MIC or lower than the MIC of SeNPs or SeS2 showed better growth than untreated cultures following incubation with 1/10 MIC or less of either of the compounds. Brief exposure of Malassezia spp. to less than the MFC of SeNPs or SeS2 may result in the proliferation of fungal cells that are less sensitive to selenium and may contribute to the recurrence of infection following treatment. Keywords: Selenium nanoparticles, Malassezia, antifungal activity, post-antifungal effec

Frikha FBahloul E  Amouri MTurki H

Cutaneous leishmaniasis may be misdiagnosed because of its similarity to other skin diseases. Keywords: Cutaneous leishmaniasis, pseudotumoral, atypical, polymorphism

Xuesheng Han Tyler Bahr

: Research on the biological activities of essential oilsin human skin cells is limited. This study first analyzed the effect of an essential oil blend (EOB) on 17 important protein biomarkers in cytokine-stimulated human dermal fibroblasts. The EOB was composed of essential oils of frankincense resin, sweet orange peel, litsea fruit, thyme plant, clove bud, summer savory plant, and niaouli leaf. The results showed that EOB had excellent antiproliferative activity. It significantly increased vascular cell adhesion molecule 1 levels and slightly increased the monocyte chemoattractant protein 1 and epidermal growth factor receptor production. We then studied the effect of the EOB on the expression levels of 21,224 genes in the same cells. We found that the EOB markedly affected genome-wide gene expression. Further analysis revealed that the EOB pleiotropically regulated multiple signaling pathways in human cells including hepatic fibrosis activation, antigen presentation, mitotic roles of the polo-like kinase, and cyclin and cell cycle regulation. Many pathways significantly affected by the EOB are closely related to inflammatory and immune responses. The results suggest that the EOB may affect biological processes and global gene expression in human skin cells. Further research into the underlying mechanism of action of the EOB is needed. Keywords: Essential oil; frankincense; sweet orange; litsea; thyme; inflammation; immune response; signaling pathway; tumor; genome-wide gene expression