Recent Update on 1,3,4-Thiadiazole Derivatives: As Anticonvulsant Agents
Abstract
1,3,4-thiadiazole is one of the most potent heterocyclic containing carbonic anhydrase and antibacterial
inhibitor from the natural and synthetic origin. It possessed potent anticonvulsant activity in wide range
preclinical in vitro and in vivo models. Recently, various 1,3,4-thiadiazole derivatives have been synthesized and
evaluated their anticonvulsant activity. This review is a demonstration to compile the medicinal chemistry,
anticonvulsant screening and their structural activity relationship as well as pharmacophoric pattern of various
synthesized 1,3,4-thiadiazole derivatives.
