American Research Journal of Endocrinology

Background: Polycystic ovarian syndrome (PCOS) is a common problem causing menstrual irregularity and infertility among women of fertile age. Increased level of anti-müllerian hormone (AMH) is currently thought to be an important marker for PCOS. Objective: Determine the AMH levels in PCOS. Methods: This cross-sectional study included 80 PCOS patients [age: 23.7±4.8, years; body mass index, BMI: 26.7±4.5 kg/m2; (mean ±SD)] diagnosed on the basis of Rotterdam 2003 criteria and 80 healthy women of fertile age as controls [age: 26.3±2.9, years; BMI: 21.7±2.8 kg/m2; (mean ±SD)]. AMH (ng/ml) was measured by enzyme linked immunosorbant assay (ELISA) whereas other hormones (follicle stimulating hormone, FSH; luteinizing hormone, LH; Testosterone) by immunochemiluminometric assay. Results: AMH was significantly higher in PCOS (9.21 ± 0.50 vs. 4.40 ± 0.41, ng/ml, M ± SE; p<0.001) than that of healthy controls. Though not statistically significant, AMH showed inverse relationship with FSH (mIU/ml, r = - 0.129; p = 0.253), and BMI (kg/m2, r = - 0.046; p = 0.686) whereas positive relationship with testosterone (ng/dl, r = 0.146; p = 0.197) and LH (mIU/ml, r = 0.102; p = 0.368). Holding cut-off value at 3.5 ng/ml for AMH, sensitivity and specificity of AMH was found to be 67% and 78.33% respectively. Conclusions: PCOS women of fertile age have higher AMH level than that of healthy control subjects. It can be considered as an important seromarker for the diagnosis of PCOS. Key words: AMH, PCOS.