Efficacy of Dental Mesenchymalstem Cells in Kidney failure 111
Citation: Efficacy of Dental Mesenchymalstem Cells in Kidney failure. American Research Journal of Urology; 2(1): 1-4
Copyright This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Kidney is one of the most important organs in human body; it has various roles in maintenance of life. Any disturbance in composition of kidney may be lead to kidney diseases, so this is reflect on the function of kidney. There are different strategies in treatment of kidney disease. Although, these techniques have useful role in treatment process but also have numerous side effect which not only effect on kidney healthy buteffect on other organs. New trend in treatment process find the way of treatment with out or with few risk. Stem cells use in treatment of different diseases. There are 2 types of stem cells; embryonic stem cells, and adult stem cells;adult stem cells include bone marrow, and teeth stem cells. All researches indicate that stem cell originated from teeth has more efficiency as compared to other types of stem cells. Dental stem cell success in treatment many complicated diseases. In this article we will discuss function of kidney,kidney diseases, stem cells dental stem cells, and its role in treatment of kidney diseases.
Key words: Kidney, kidney failure, stem cell, dental stem cell.
Kidneys are the body’s filtering units, which located in the direction of the back of the body, approximately 10 cm above the hipbones and below the ribcage. Kidney play a vital role in maintaining balance of fluid, minerals, salts and other substances in the blood. They are responsible for removing waste and toxic substances from the body through the urine. In addition to they produce numerous hormones as erythropoietin, which responsible for production of red blood cells; calcitriol, which increase the rate of absorption of calcium and play important role in bone mineralization; and renin, which is enzyme involved in controlling blood pressure Fig.1. .
Kidneys are consist from small units which called nephrons, any disturbance in these cells lead to uncontrolling of kidney functions, and development of many kidney diseases. Kidney diseases generally involve damage to the nephrons and can be acute or chronic . In acute kidney disease there is a speedy drop in kidney function. This occurs by loss of large amounts of blood or an accident. While chronic kidney disease (CKD) is well-defined as loss of a third or more of kidney function for at least three months. The risk of developing CKD is increased by age, diabetes, high blood pressure, obesity and smoking. At least 8% of the people in Europesuffer from CKD, and these people have great risk for developing kidney failure. This risk is increasing every year and there are not enough volunteers to provide transplants for these patients. So most of researchers make all efforts to development of new therapeutic options for treating CKD .
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