Pediatric Patients and Pain 111
Citation: Pediatric Patients and Pain. American Research Journal of Pediatrics; 1(1): 25-37.
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Pain is an important part of the disease; it’s the first evident symptom. Recently it is not considered anymore by the researchers and the doctors as a symptom, but as a specific disease, defined as “The Fifth Vital Sign”.
Pain assessment is an essential element for the treatment. The success of a good analgesic management is based firstly in the valuation of the pain according to the scales.
The Faces pain scale is used for children 4-7 years old, while the Visual analog Scale(VAS) is used for children above this age.
A study from December 1, 2011 to May 31, 2012, was used to assess the acute pain levels among 177 children from birth to 13 years old in Obstetrics and Gynecology Hospital, an University Hospital Centre, a Pediatric Hospital and an Outpatient Services in Tirana. For patients incapable to verbalize the pain intensity in a reliable way (neonates to the age of four years old), the hetero-evaluation was used. The hetero-evaluation is realized only with one assessment scale, while patients older than 4 years and younger than 6 years old were assessed using the hetero-evaluation and auto-evaluation scale according to the Faces Scale and VAS.
The assessment according to VAS is applied in two positions, horizontally and vertically. The results obtained from the different scales and the VAS positions are compared. The NFCS and the Faces Scale are much more easily accessible by the nursing staff; while the multidimensional scales (OPS, CRIES, PIPP) were found more difficult to be used.
Keywords: pediatric patients; pain treatment; visual analogue scale.
The medical science is becoming more and more sophisticated, but unfortunately there is more to do with the pain management. Adults are the first persons that benefited from the recent researches in this direction, mainly in the last two decades; meanwhile “uncommonly”, the pain is still untreated or insufficiently untreated among the children.
Physical pain is not just a transmission of electrical impulses in the correspondly sectors; it’s considered as a “conflict” between the stimulant and the person that is suffering. Unrelieved pain may cause anxiety and stress, or in other cases even psychological and behavioral long term consequences.
Pain is an important part of the disease; it’s the first evident symptom.  Recently it is not considered anymore by the researchers and the doctors as a symptom, but as a specific disease, defined as “The Fifth Vital Sign”. Synchronal with this reconception, there are other new notions like nervous system hypersensitivity caused by the acute pain and the rehabilitation, known for their important role due to major developments in the multimodal analgesia.
Last years the researches are mostly focused on pain assessments as the main element that precedes the treatment.  There is used a specific number of assessments scales to measure the pain, mainly for the acute pain; but none of them fulfill at the same the criteria of validity, reliability and applicability. Anyways, we can say that there are adopted some assessment scales according the researches or for daily use only.
Pain assessment is an essential element for the treatment. The success of a good analgesic management is based firstly in the valuation of the pain according to the scales. 
Schematically, we can say that we use the behavioral scale like NFCS or CHEOPS or multidimensional scales (that combine the physiological markers like Pam or SpO2 with the behavioral variations) like OPS, PIPP, CRIES, etc. to diagnose the children.
Pain assessment is based in two groups of measurement: the measurement of physiological parameters  and the measurement of behavioral factors.   The physiological factors (like tachycardia, tachypnea, sweating, and the increase of arterial pressure) are always part of the pain, but they are not specific. Therefore, the behavioral scales are the main modalities used to assess the pain in neonates, infants and children under 4 years old that are not capable of verbal communication. These scales are based on facial expressions (crying or grimace), motor response, the vision and verbal response; for example the FLACC scale.
Although there is a considerable number of pain assessment scales, only some of them could be used for practical intention. We can use the FLACC scale for abovementioned age-group. The Faces Pain Scale is used for children 4 to 6-7 years old, while the Visual Analog Scale (VAS) is used for children above this age.
PURPOSE OF THE STUDY
To recognize the physiopathological mechanisms behind the pain and these assessment and treatment methods applied to pediatric patients in order to compile the diagnosis and medical intervention, increasing in this way the treatment effectiveness.
1. To describe the pain characteristics of the pediatric patient and its physiological consequences to the body.
2. To describe the criteria of pain assessment scale selection according to the children age and pain type.
3. To know more about using pharmaceuticals and non pharmaceuticals methods in treating pain.
MATERIALS AND METHODS
A 7-months study from December 1, 2011 to May 31, 2012, was used to assess the acute pain among 177 children from birth to 13 years old in Obstetrics and Gynecology Hospital, University Hospital Centre, Pediatric Hospital and Outpatient Services in Tirana.
For patients, incapable to verbalize the pain intensity in a reliable way (neonates to <4years old), it is used the hetero-evaluation. The hetero-evaluation is realized only with one assessment scale.
While patients ≥4 years old and < 6 years old are assessed using the hereto-evaluation and auto-evaluation scale according to the Faces Scale and VAS.
The auto-evaluation of the acute pain intensity is applied according to two different assessment scales, consisting in the same procedure, on the same patients. The assessment according to VAS is applied in two positions, horizontally and vertically. The results obtained from the different scales and the VAS positions are compared between one another.
The auto-evaluation scales are combined as below:
• VAS/ NRS
• VAS/ Faces Scale
Pain is divided in 4 different levels, for all the scales:
According to Consensus Conference “Évaluation et Stratégies de Prise en Charge de la DouleurAiguë chez l’Enfant de 1 Mois à 15 Ans”, ANAES, March 2000.
The population taken in consideration for the study is divided in 4 age-groups according to the suitable usage of the assessment scales, and it is represented in the table below
The assessment is applied among 177 patients, 40.1% of them females and 59.9% males.
The division according to the type of pain (postoperative/acute non postoperative) is represented below:
The patients are distributed as below according to the pain type and the gender:
In the table below, it is represented the distribution of the patients according to age-group, associated with the graphical presentation:
In relation to the pain level, the information about the surveyed patients is represented in the table and the graphic below:
Scoring averages of different scales according to age-groups are represented in the table below. Since there are used two different positions of VAS (horizontal and vertical), all the information below is given separated according to the different variants (in which VASH is the horizontal variant and VASV is the vertical one).
The scoring system for the Face Scale, NFCS, VAS, OPS, CRIES and NRS is 0-10.
While, for the CHEOPS (4-13) and PIPP (0-21) scales is applied the conversion of the average values to the 0-10 system.
According to the study’s results, the percentage of postoperative patients with intense pain is 47.62% and with maximum pain is 52.38%. There are 5.77% non-postoperative patients with moderate pain, 55.77% with intense pain and 38.46% with maximum pain. In conclusion, all postoperative patients and 94.23% of nonpostoperative children undergoing painful procedures experienced intense and maximum pain. 
The average of the obtained results using all the scales varies in that way to show intense or maximum pain levels, as well.
Most of the researchers claim that if we compare the pain levels between males and females, the first ones are lower, but it is not considered as statistically significant (p>0.05 for all the scales). However, we should take in consideration the fact that the auto-evaluation is applied among a small sample (24 patients-13.56%). 
The previous studies indicate different levels of scoring, using the visual analog scale (VAS) in two different orientations-horizontal and vertical. Researchers argue that there are inequalities because of the difficulties among the children’s spatial orientation, from 0-10 years old. 
The NFCS and the Faces Scale are much more easily accessible by the nursing staff; while the multidimensional scales (OPS, CRIES, PIPP) were found more difficult to be used. This because of:
1. The considerable number of parameters to be assessed and saved in epidemiological files.
2. In many cases, there is not the required information about the levels of AP before and after the procedure.
3. Since there are required the reference values (the values of parameters before the surgical intervention or before the painful procedure), that could not be always documented.
The presence of parents during the auto-evaluation has played an important role in children’s maximal collaboration, increasing in this way the obtained data validity.
Pain treatment consists in providing a maximum pain relief and a minimum of side effects. The multimodal analgesia is considered to be as the most suitable method, based on the synergistic effects of different analgesics, decreasing the necessity of using high doses and the incidence of adverse effects of them.
Mild and moderate pain: could be used medicaments as paracetamol, NSAIDs (ibuprofen, naproxen, ketoprofen) and mild opioids (codeine, tramadol, dextropropoxyphene).
Average pain intensity: could be used opioids, accompanied with NSAIDs.
Intense pain: there are recommended major opioids (morphine, fentanyl, hydrocodone, oxycodone). NSAIDs could be used to increase the opioid’s effects. 
Local anesthetics could be used as peridural and intrathecal administration.
There are two types of analgesics: minor and major, or opioids and non opioids. 
Acetaminophen (Paracetamol) is a minor analgesic that increases the effects of analgesia when it is used with another major analgesic. It is the most widely used analgesic among children for oral and rectal use. The optimal dose of acetaminophen it is not exactly defined, but usually it is used 10-15mg/k, oral use. High doses of acetaminophen used in children with serious infections are considered as an indication for hepatic insufficiency. Therefore, it is suggested to be used for short period of times .
Ibuprofen is a non sterioid anti inflamator drug used mainly to treat the pain and temperature among children.  It is suggested a 15mg/kg dose for oral use to have an analgesic effect. However, for a repeated dose among 6 months to 12 years old children, it is suggested a dose of 10 mg/kg, every 6h oral use (maximum daily dose-40 mg/kg).
Naproxen has a longer half-life than ibuprofen, therefore it could be used every 8-12h. It is not known any information about the effect on infants. The usual or normal dose is considered 5-10 mg/kg oral use, every 8-12 h (maximum daily dose-20 mg/kg). 
Opioid analgesics are used by the nursing staff under strict supervision of a doctor, because of the serious side effects, such as inhibition of respiration. 
Opioids are used to treat pain among patients of different ages. If the dosage is correct, the analgesic effects among children could be easily distinguished. There are different routes of administration available for opioids, including oral, intravenous, rectal, transmucosal or transdermal administration. It is important to avoid the intramuscular or subcutaneous route to pediatric patients. Most of opioids are available in liquid forms and could be easily applied to children with difficulties in managing the opioid pills. Recently, to manage neoplastic pain treatment among children, it is used Fentanyl Transdermal Patch or other forms of Fentanyl.
Sedatives are mostly used for their calming or sleep-inducting effect to reduce pain. 
The reasons why the pain could not be treated with opioids:
1. Side effects, such as respiratory depression.
3. Insufficient information possessed by the staff about these drugs.
Skin stimulation relieves pain, as well. There are used different techniques such as pressure, massage, vibration, heat and cold therapy, oily treatment which are considered to be very effective and safe (Woolf & Thompson, 1994). The activation of Aβ big fibers and the inhibition of Aδ and C small fibers, which close the pain “gate”, can cause sedative effects. 
Friction massage applied to the painful region could relax the muscles and decrease the tension. It is not recommended to the damaged skin since it could enlarge the damage. Skin irritation could be treated with menthol products, which contain methyl salicylate that could be absorbed, causing an analgesic effect in the affected area. Heat and cold therapy are use to decrease muscular pain (Lehmann and De Lateur).  The immediate change of temperature, from heating to cold can cause analgesic effect that could last for hours. But, this is a method that can not be used within the first 24 hours to a traumatized area. Cold therapy reduces blood circulation causing positive effects, but preliminary we should take in consideration some advices about heat and cold therapy:
• To not use cold therapy to a hypovascular area
• To avoid extreme temperatures that can cause burn or freezing injuries
• To not apply heat therapy to a fresh wound because it might cause or increase bleeding
• To stop the application if the pain is increasing
In this case, the opposite areas are stimulated using pressure, massage, ice, heat and cold therapy or menthol to release pain (for example, when the right hand is damaged, we stimulate the left hand). It could be used when the affected areas are not exposed because of plasters, bandages or when the skin is irritated.
Transcutaneous Electrical Nerve Stimulation (TENS)
TENS by definition covers the complete range of transcutaneously applied currents, with low voltage, transmitted to the affected area through some electrodes. It produces analgesics effects through Aβ fibers stimulation and Aδ fibers inhibition.
Skin irritation could be a side effect caused by the electrode stickers. This could be avoided using hypoallergenic stickers, while redness could be avoided by cleaning the electrodes with soapy water. Contraindications of TENS include the application in eyes, forehead, mouth, neck. It is still not approved that TENS could perform safety during the very first months of pregnancy, butit is used to lower back part after it (McCaffery, 1979).
Recognition of Pain Relief Techniques
It is really helpful for patients that are passing difficulties moments like intense pain, clothing difficulties, great physical disability. The visual entertainment includes reading, picture slideshows, listening to music, playing an instrument or playing with a pet etc. Pain relief is temporary, but if the patient likes what he is doing, the results will be positive.
Roadmap for Managing Pain
It is a technique in which patient is focused in pleasant, imaginative or visual situations, finding this as a good option to be relaxed.
Hypnosis depends on how much the consciousness of patients is influenced. This technique replaces the pain perception with another sensation (Syrjala, Cummings, and Donalds, 1992). Generally, around 20% of hypnotized patients have successfully confronted pain (Syrjala, et.al.1992). But it is rarely applied because it is an expensive procedure, requires a lot of time to be performed and a qualified staff.
Relaxation, meditation, sedation are techniques that could control pain, as well.
It is a method that trains patients to control certain bodily processes that normally happen involuntarily, such as heart rate, respiratory rate and muscle tone. Relaxation decreases pain, decreasing the anxiety as well, and increasing pain control.
Fear and death could accelerate pain levels. Sharing emotionally patient’s experiences is as important as the treatment (Johnson, 1972; Johnson, Nail, Lauver, King, & Keys, 1988). 
1. Assessment is the first step toward the appropriate postoperative and procedural acute pain management.
2. The correct usage of assessment scales, according to a standard protocol ensures to truthfully measure pain intensity, being the “key to success” for the necessary information used to create the pain treatment modalities.
1. A part of pediatric patients are not capable to give information referred to the experienced pain. Therefore, it is a staff obligation to improve their knowledge toward pain assessment.
2. It is suggested a continuous pain assessment in order to have an efficient treatment.
3. There should be avoided the abuse with painful procedures (to replace, if it is possible, the parenteral administration route of medicaments with the oral one). 
4. To choose the less painful procedure for application.
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