Factors Regulating Acute Radiodermatitis A Prospective Study


Aicha Nassiri*

Citation: Factors Regulating Acute Radiodermatitis - A Prospective Study. American Research Journal of Dermatology; 1(1): 38-43.

Copyright This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract:

Introduction: Radiodermatitis can cause a real discomfort for patients and can lead to the cessation of the treatment. The aim of our study was to identify different factors regulating acute radiodermatitis.

Material and Methods: From January 2016 to December 2017, We conducted a prospective trial with collaboration of dermatologist and radiotherapist of hassan II hospital in Fez.

Results: Radiodermatitis stage 1 were found in 20%. The predominent irradiated area in this stage was face and neck in 42% and breast in 27%.

Radiodermatitis stage 2 were seen in 40%. 41% in head and neck and 24% in the breast.

Radiodermatitis stage 3 were found in 23%. Radidermatitis STAGE 3 were seen only in 3 areas : perineal area (59%), face and neck (22%), breast (19%).

Radiodermatitis stage 4 in 17% seen only in 2 areas : perineal 72%, face and neck in 27%.

Conclusion: Radiodermatitis is one of the most common side effects experienced by patients undergoing radiotherapy. In our study the factors influencing radiodermatitis were age of the patient, sexe, obesity, smoking, perineal location, photoexposed areas, higher radiation doses.

Keywords: Acute radiodermatitis, regulating factors, Radiotherapy side effects


Description:

INTRODUCTION

Radiotherapy is used to treat several types of cancer ( breast, digestive, nasopharynx, prostat,....).It is described that more than half of these patient will develop radiodermatitis also known as radiation induced skin cancer or radiation injury of the subdermal fat. (1, 2, 3) These radiation dermatitis have been recognised since the beginning of the 20th century. (4, 5)

Radiodermatitis can cause a real discomfort for patients and can lead to the cessation of the treatment. (1, 5)

The need of treating and preventing this dermatitis had pushed many clinicians to explore the underlying factors and management of radiodermatitis. But despite this growing interest, much remains to be discovered.

MATERIAL AND METHODS

From January 2016 to December 2017, We conducted a prospective trial with collaboration of dermatologist and radiotherapist of hassan II hospital in Fez.

Every day, a dermatologist was available in the radiotherapy departement, to examine all the patient undergowing a radiotherpy treatment that day. Pictures were taken for all the patient at the first time and in each follow-up.

Inclusion criteria used are:

patients undergowing radiotherapy treatement

Patients presenting dermatoses in patients on the areas of radiation.

The search strategy employed MeSH terms and keywords designed to optimize the identification of randomized trials, guidelines, and systematic reviews on radiation dermatitis for acute reactions.

Every day, a dermatologist was available in the radiotherapy departement, to examine all the patient undergowing a radiotherpy treatment that day. Pictures were taken for all the patient at the first time and in each follow-up.

We used the Radiation Therapy Oncology Group (RTOG) for the classification of acute dermatitis (3,6).

All Data was noted on excel, statisctical analysis was made using Epi info.

The trial protocol was approved by the Institutional Ethical Committee of the Hassan II University Hospital. Informed, written consent of all participants was taken prior to enrolment.

RESULTS

The study was conducted since march 2016 until december 2017, 174 patients have been included. 125 females and 49 males developped a radiodermatitis in different stages. Patients were aged between 14 and 74 years with a mean age of 34,4. More than 60% of the patient had a body mass index > 30 and 37% were smokers.

70% were having a concomittant chemotherapy. 83 % case were irradiated on the neck and face (parotid, maxillary sinus, larynx,..), 30% were irradiated on the perineal area (uterine cervix, rectum, prostat,...), 55% were irradiated on the breast (breast cancer), 2 patients were irradiated on the extremities one on the elbow and the other on the thigh . 

The staging of patients was done regarding the area of irradiation.

Radiodermatitis stage 1 were found in 20%. The predominent irradiated area in this stage was face and neck in 42% and breast in 27%.

Radiodermatitis stage 2 were seen in 40%. 41% in head and neck and 24% in the breast. Radiodermatitis stage 3 were found in 23%.

Radidermatitis STAGE 3 were seen only in 3 areas : perineal area (59%), face and neck (22%), breast (19%).

Radiodermatitis stage 4 in 17% seen only in 2 areas : perineal 72%, face and neck in 27%.